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- Title
Stimulation of 5-hydroxytryptamine (5-HT[sub 2C] ) receptors in the ventrotegmental area inhibits stress-induced but not basal dopamine release in the rat prefrontal cortex.
- Authors
Pozzi, Laura; Acconcia, Sabrina; Ceglia, Ilaria; Invernizzi, Roberto W.; Samanin, Rosario
- Abstract
The present study investigated whether 5-HT[sub 2C] receptors in the ventrotegmental area and prefrontal cortex regulate basal and stimulus-evoked dopamine release in the prefrontal cortex. Using the in vivo microdialysis technique in conscious rats, we studied the effect of a selective 5-HT[sub 2C] receptor agonist, Ro60-0175, on basal and immobilization stress-induced dopamine release in the prefrontal cortex. Ro60-0175 intraperitoneally (2.5 mg/kg) and into the ventrotegmental area (10 µg/0.5 µL) completely antagonized the effect of stress on extracellular dopamine without altering basal levels. Infusion of 10 µM RO60-0175 through the cortical probe had no significant effect on basal and stress-induced dopamine release. SB242084 (10 mg/kg), a selective antagonist of 5-HT[sub 2C] receptors, significantly increased basal extracellular dopamine and completely prevented the effect of intraperitoneal and intraventrotegmental Ro60-0175 on the stress-induced rise of extracellular dopamine, but had no effect itself in stressed rats. The results show that Ro60-0175 suppresses cortical dopamine release induced by immobilization stress through the stimulation of 5-HT[sub 2C] receptors in the ventrotegmental area. While confirming that endogenous 5-HT acting on 5-HT[sub 2C] receptors tonically inhibit basal dopamine release in the prefrontal cortex, the present findings suggest that the stimulation of 5-HT[sub 2C] receptors with an exogenous agonist preferentially inhibit stimulated release.
- Subjects
SEROTONIN; DOPAMINE; PREFRONTAL cortex; RAT physiology
- Publication
Journal of Neurochemistry, 2002, Vol 82, Issue 1, p93
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1046/j.1471-4159.2002.00947.x