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- Title
The multiple paradoxes of presenilins: MINI REVIEW.
- Authors
Checler, F.
- Abstract
Presents some objective experimental and theoretical arguments against a direct role of presenilins as proteases. Theoretical and conceptual problems facing the hypothesis that presenilins are the genuine gamma-secretases; Need to review studies aimed at delineating the sensitivity of beta-amyloid-generating activities into various classes of inhibitors.
- Subjects
PRESENILINS; PROTEOLYTIC enzymes
- Publication
Journal of Neurochemistry, 2001, Vol 76, Issue 6, p1621
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1046/j.1471-4159.2001.00244.x