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- Title
Roles of lipid droplets and related proteins in metabolic diseases.
- Authors
Zhang, Zhongyang; Yu, Zhenghang; Liang, Dianyuan; Song, Ke; Kong, Xiangxin; He, Ming; Liao, Xinxin; Huang, Ziyan; Kang, Aijia; Bai, Rubing; Ren, Yixing
- Abstract
Lipid droplets (LDs), which are active organelles, derive from the monolayer membrane of the endoplasmic reticulum and encapsulate neutral lipids internally. LD-associated proteins like RAB, those in the PLIN family, and those in the CIDE family participate in LD formation and development, and they are active players in various diseases, organelles, and metabolic processes (i.e., obesity, non-alcoholic fatty liver disease, and autophagy). Our synthesis on existing research includes insights from the formation of LDs to their mechanisms of action, to provide an overview needed for advancing research into metabolic diseases and lipid metabolism.
- Subjects
METABOLIC disorders; NON-alcoholic fatty liver disease; LIPID metabolism; ENDOPLASMIC reticulum; LIPIDS
- Publication
Lipids in Health & Disease, 2024, Vol 23, Issue 1, p1
- ISSN
1476-511X
- Publication type
Article
- DOI
10.1186/s12944-024-02212-y