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- Title
Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs.
- Authors
de Castro Cunha, Rúbia Monteiro; Santos Horta, Rodrigo dos; Eunice Lavalle, Gleidice; Baracat Araújo, Roberto
- Abstract
Targeted therapy of neoplasms is an emergent approach in human and veterinary medicine. Cyclooxygenase (COX) is a class of catalytic enzymes related to the formation of inflammatory mediators. COX-2 is expressed constitutively in a few body tissues, but it may be induced in specific pathophysiologic conditions, such as cancer. COX-2 expression in neoplams may be considered a potential predictive factor, due to the possible association of selective COX-2 inhibitors in adjuvant treatments. This scientific communication has the objective to report COX-2 expression in seven neoplasms of dogs and the usage of adjuvant treatment with COX-2 selective inhibitors as an effective and feasible option in cancer treatment.
- Subjects
EPITHELIAL cell tumors; CYCLOOXYGENASE 2 inhibitors; CANCER in dogs; CYCLOOXYGENASE 2; ADJUVANT treatment of cancer; IMMUNOHISTOCHEMISTRY; CANCER treatment; TUMOR treatment; THERAPEUTICS
- Publication
Ciência Rural, 2016, Vol 46, Issue 6, p1050
- ISSN
0103-8478
- Publication type
Article
- DOI
10.1590/0103-8478cr20150794