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- Title
Translocation of PKCθ in T cells is mediated by a nonconventional, P13-K- and Vav-dependent pathway, but does not absolutely require phospholipase C.
- Authors
Villalba, Martin; Kun Bi; Hu, Junru; Altman, Yoav; Bushway, Paul; Reits, Eric; Neefjes, Jacques; Baier, Gottfried; Abraham, Robert T.; Altman, Amnon
- Abstract
Examines the role of P13-K- and Vav-dependent pathway in regulating PKC family translocation in T cells. Mechanism of mature T cells activation; Correlation between T cells and PKC enzymes; Importance of actin cytoskeleton organization in Vav/Rac pathway activity.
- Subjects
T cells; CHROMOSOMAL translocation
- Publication
Journal of Cell Biology, 2002, Vol 157, Issue 2, p253
- ISSN
0021-9525
- Publication type
Article
- DOI
10.1083/jcb.200201097