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- Title
Dynamic Neutrophil–Lymphocyte Ratios Predict Short-term Prognostic Outcome of Thrombolysis in Patients with Acute Ischemic Stroke.
- Authors
Weng, Yiyun; Hu, Jingyu; Ren, Junli; Huang, Honghao; Yang, Chenguang; Shen, Jiamin; Pan, Wenjing; Sun, Fangyue; Qiu, Haojie; Gao, Yufan; Li, Shengqi; Huang, Xuerong; Chen, Guangyong
- Abstract
Aim: The main purpose of this study was to investigate the dynamic changes of neutrophils-lymphocytes ratios (NLRs) in patients with acute ischemic stroke (AIS) and their relationships with 3-month prognostic outcomes. Methods: Two hundred ninety-one patients with AIS were included in this study, followed up for 3 months. At admission, 1 and 7 days after recombinant tissue plasminogen activator (r-tPA) injection, blood samples were obtained. Outcome events included excellent outcome, good outcome, and death defined as modified Rankin Scale (mRS) scores of 0–1, 0–2, and 6 respectively. Results: NLRs measured in admission and 7 days after r-tPA treatment were associated with prognosis outcome after 3 months. Twenty-four-hour NLR is an excellent indicator in forecasting (excellent outcome's the areas under the curve (AUC) = 0.725; good outcome AUC = 0.742; death AUC = 0.759). In addition, we were surprised to find that dynamic increase in NLR within 24 h is significantly related to excellent and good outcomes. Conclusions: Twenty-four-hour NLR is related to the severity of AIS and poor prognosis, which can help early risk stratification. Significance: We can predict the prognosis of AIS more accurately. Compared with previous studies, our study has shown the dynamic changes of NLR and its relationship with NIHSS and multiple prognostic.
- Subjects
LYMPHOCYTE count; STROKE patients; NEUTROPHIL lymphocyte ratio; TREATMENT effectiveness; TISSUE plasminogen activator; PROGNOSIS
- Publication
Neurotoxicity Research, 2021, Vol 39, Issue 5, p1678
- ISSN
1029-8428
- Publication type
Article
- DOI
10.1007/s12640-021-00382-6