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- Title
Synthesis of the Disialic Acid-Embedded Glycan Part of Ganglioside HPG-1.
- Authors
Shimizu, Hiroyo; Iwayama, Yuki; Akihiro Imamura; Ando, Hiromune; Ishida, Hideharu; Kiso, Makoto
- Abstract
The article focuses on a study that highlights the synthesis of tetrasaccharide portion of ganglioside HPG-1. It notes that gangliosides from echinoderms have potential as drug seeds in combating neuronal disorders. Furthermore, ganglioside HPG-1was isolated from the sea cucumber Holothuria pervicax together structurally related to HPG-7 and 8 demonstrating the neuritogenic activity toward rat pheochromocytoma PC-12 cell.
- Subjects
GANGLIOSIDES; ECHINODERMATA; HOLOTHURIA; PHEOCHROMOCYTOMA; OLIGOSACCHARIDES
- Publication
Bioscience, Biotechnology & Biochemistry, 2011, Vol 75, Issue 10, p2079
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.110619