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- Title
β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma).
- Authors
Suzuki, Yuka; Ichihara, Shu; Kawasaki, Tomonori; Yanai, Hiroyuki; Kitagawa, Satoshi; Shimoyama, Yoshie; Nakamura, Shigeo; Nakaguro, Masato
- Abstract
Sinonasal glomangiopericytoma (SN-GPC) is an uncommon mesenchymal tumor with myoid differentiation. Recently, mutations in exon 3 of the gene coding for β-catenin (CTNNB1) and its nuclear expression were discovered in SN-GPC. β-catenin protein is a key regulatory molecule of the canonical Wnt signaling pathway. The expression of β-catenin target proteins is not well characterized in SN-GPC. We examined three SN-GPCs by immunohistochemistry and CTNNB1 mutation analysis. All cases expressed nuclear β-catenin. We identified CTNNB1 exon 3 mutations in two analyzable cases. Lymphoid enhancer-binding factor 1 (LEF1), a protein downstream from β-catenin, was also expressed in all cases. Our results further characterized the activation of the Wnt signaling pathway caused by CTNNB1 exon 3 mutation and suggest the utility of LEF1 immunohistochemistry in the differential diagnosis of SN-GPC.
- Subjects
NASAL tumors; CATENINS; GENETIC mutation; GENE expression; LYMPHOID tissue; INSECT genetics; GENE enhancers
- Publication
Virchows Archiv: European Journal of Pathology, 2018, Vol 473, Issue 2, p235
- ISSN
0945-6317
- Publication type
journal article
- DOI
10.1007/s00428-018-2370-9