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- Title
One-Pot Synthesis of (1,2,3-Triazolyl)methyl 3,4-Dihydro-2-oxo-1 H-pyrimidine-5-carboxylates as Potentially Active Antimicrobial Agents.
- Authors
Dabiri, Minoo; Salehi, Peyman; Bahramnejad, Mahboubeh; Koohshari, Majid; Aliahmadi, Atousa
- Abstract
A simple and efficient one-pot four-component procedure has been developed for the synthesis of a wide range of compounds containing the (triazolyl)methyl oxo-pyrimidine-carboxylate system from propargyl β-keto esters, various azides, aldehydes, and urea in the presence of catalytic amounts of (AcO)2Cu/sodium ascorbate in AcOH. The method worked well with different aryl and heteroaryl aldehydes, and for a variety of substituents in the triazolyl part of the molecule. The antimicrobial activities of the products were evaluated against two Gram-positive and Gram-negative bacteria, and one fungus. Compound 5j was active against Staphylococcus aureus and Candida albicans.
- Subjects
CHEMICAL synthesis; PYRIMIDINES; ANTI-infective agents; CARBOXYLATES; STAPHYLOCOCCUS aureus infections; CANDIDA albicans; THERAPEUTICS
- Publication
Helvetica Chimica Acta, 2014, Vol 97, Issue 3, p375
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201300198