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- Title
Novel methods in adrenal research: a metabolomics approach.
- Authors
Papathomas, Thomas G.; Sun, Na; Chortis, Vasileios; Taylor, Angela E.; Arlt, Wiebke; Richter, Susan; Eisenhofer, Graeme; Ruiz-Babot, Gerard; Guasti, Leonardo; Walch, Axel Karl
- Abstract
Metabolic alterations have implications in a spectrum of tissue functions and disease. Aided by novel molecular biological and computational tools, our understanding of physiological and pathological processes underpinning endocrine and endocrine-related disease has significantly expanded over the last decade. Herein, we focus on novel metabolomics-related methodologies in adrenal research: in situ metabolomics by mass spectrometry imaging, steroid metabolomics by gas and liquid chromatography-mass spectrometry, energy pathway metabologenomics by liquid chromatography-mass spectrometry-based metabolomics of Krebs cycle intermediates, and cellular reprogramming to generate functional steroidogenic cells and hence to modulate the steroid metabolome. All four techniques to assess and/or modulate the metabolome in biological systems provide tremendous opportunities to manage neoplastic and non-neoplastic disease of the adrenal glands in the era of precision medicine. In this context, we discuss emerging clinical applications and/or promising metabolic-driven research towards diagnostic, prognostic, predictive and therapeutic biomarkers in tumours arising from the adrenal gland and extra-adrenal paraganglia as well as modern approaches to delineate and reprogram adrenal metabolism.
- Subjects
METABOLOMICS; LIQUID chromatography-mass spectrometry
- Publication
Histochemistry & Cell Biology, 2019, Vol 151, Issue 3, p201
- ISSN
0948-6143
- Publication type
Article
- DOI
10.1007/s00418-019-01772-w