We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A review of the potential protective effects of pentoxifylline against drug-induced nephrotoxicity.
- Authors
Nasiri-Toosi, Zahra; Dashti-Khavidaki, Simin; Khalili, Hossein; Lessan-Pezeshki, Mahboob
- Abstract
Purpose: Drug-induced nephrotoxicity is one of the most common side effects of medications and accounts for about 20 % of hospital admissions for acute kidney injury (AKI). Some possible pharmacologic mechanisms of pentoxifylline (PTX) that suggest it as a candidate to ameliorate AKI include interaction at the level of the adenosine receptors, increase in erythrocyte deformability, stimulation of vasodilatory prostaglandins production and prevention of vascular congestion, and suppression of tumor necrosis factor alpha (TNF-α) and apoptosis. This manuscript reviews all clinical and animal studies on the use of PTX as a renoprotective agent against a number of nephrotoxic drugs. Methods: Data were collected by searching MEDLINE, PubMed, Scopus, Cochrane central register of controlled trials, and Cochrane database systematic reviews. Key words used as search terms were pentoxifylline, nephroprotective, renoprotective, drug-induced renal diseases, drug-induced nephrotoxicity, drug-induced renal toxicity, and drug-induced nephropathy. This search was performed without time limitation. Results and conclusion: Most greatest number of studies and human clinical trials on the renoprotective effect of PTX against drug-induced nephrotoxicity involves cyclosporine (Cyc). It seems that despite encouraging results from animal studies, there is insufficient evidence to support the renoprotective effect of PTX against Cyc-induced nephrotoxicity in humans. Although some available animal studies show protective effects of PTX against renal toxicity of some antimicrobial and cytotoxic agents, designing clinical trials to approve these nephroprotective effects requires prior confirmation of no reducing antimicrobial or antitumor action of these medications by PTX.
- Subjects
NEPHROTOXICOLOGY; PENTOXIFYLLINE; ACUTE kidney failure; ANIMAL experimentation; ANTI-infective agents; ANTINEOPLASTIC agents; IMMUNOSUPPRESSIVE agents; INFORMATION storage &; retrieval systems; MEDICAL databases; MEDLINE; ONLINE information services; PRIORITY (Philosophy); RESEARCH evaluation; SYSTEMATIC reviews; CONTRAST media; PREVENTION; THERAPEUTICS
- Publication
European Journal of Clinical Pharmacology, 2013, Vol 69, Issue 5, p1057
- ISSN
0031-6970
- Publication type
Article
- DOI
10.1007/s00228-012-1452-x