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- Title
Measure and risk: cystatin C, creatinine and controversy in CKD.
- Authors
Stevens, Kate I; Lees, Jennifer S
- Abstract
In other populations, e.g. potential living kidney donors, reliably measuring GFR is paramount because failing to do so could result in acceptance of individuals with reduced GFR or rejection of potential donors who in fact do have acceptable kidney function for donation. Therefore, if mGFR is unavailable, eGFR using SCr is more accurate than eGFR using cysC to determine clinical outcomes due purely to reduced kidney function in the kidney transplant population. Cystatin C as a measure of GFR in kidney transplant recipients CV disease is the leading cause of death in kidney transplant patients and a risk factor is graft function. Both SCr and cysC are flawed markers of kidney function due to non-GFR determinants, yet in fact there is no perfect measure of kidney function because even the "gold standard" of mGFR displays considerable measurement variability [[5]].
- Subjects
CYSTATIN C; CREATININE; CHRONIC kidney failure
- Publication
Nephrology Dialysis Transplantation, 2023, Vol 38, Issue 8, p1785
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfad113