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- Title
Hydrogen sulphide-generating pathways in haemodialysis patients: a study on relevant metabolites and transcriptional regulation of genes encoding for key enzymes.
- Authors
Perna, Alessandra F.; Luciano, Maria Grazia; Ingrosso, Diego; Pulzella, Paola; Sepe, Immacolata; Lanza, Diana; Violetti, Eleonora; Capasso, Rosanna; Lombardi, Cinzia; De Santo, Natale G.
- Abstract
Background. Hydrogen sulphide, H2S, is the third endogenous gas with putative cardiovascular properties, after nitric oxide and carbon monoxide. H2S is a vasorelaxant, while H2S deficiency is implicated in the pathogenesis of hypertension and atherosclerosis. Cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulphurtransferase (MPS) catalyze H2S formation, with different relative efficiencies. Chronic kidney disease (CKD) is characterized by elevation of both plasma homocysteine and cysteine, which are substrates of these enzymes, and by a high prevalence of hypertension and cardiovascular mortality, particularly in the haemodialysis stage. It is possible that the H2S-generating pathways are altered as well in this patient population.
- Subjects
HYDROGEN sulfide; HEMODIALYSIS patients; METABOLITES; ENZYMES; CYSTATHIONINE gamma-lyase
- Publication
Nephrology Dialysis Transplantation, 2009, Vol 24, Issue 12, p3756
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfp378