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- Title
An evaluation of maternal serum dynamic thioldisulfide homeostasis and ischemia modified albumin changes in pregnant women with COVID-19.
- Authors
Erol, Seyit Ahmet; Anuk, Ali Taner; Tanaçan, Atakan; Semiz, Handan; Keskin, Hüseyin Levent; Neşelioğlu, Salim; Erel, Özcan; Tekin, Özlem Moraloğlu; Şahin, Dilek
- Abstract
Objective: It is thought that oxidative stress, free radicals, reactive oxygen species and reactive nitrogen species affect the pathophysiology of coronavirus disease-2019 (COVID-19). This study aimed to evaluate the oxidative status in pregnant patients with COVID-19 infection according to the changes seen in the levels of maternal serum thiol-disulfide and ischemia-modified albumin (IMA). Materials and Methods: A study group was formed of 40 pregnant women with confirmed COVID-19 infection (study group) and a control group of 40 healthy pregnant women with no risk factors determined. In this prospective, case-controlled study, analyses were made of the maternal serum native thiol, total thiol, disulfide, IMA, and disulfide/native thiol concentrations. Results: The maternal serum native thiol and total thiol concentrations in the study group were determined to be statistically significantly lower (p=0.007 and p=0.006, respectively), and the disulfide/native thiol ratio was higher but not to a level of statistical significance (p=0.473). There was no difference between the two groups regarding IMA levels (p=0.731). Conclusion: The thiol-disulfide balance was seen to shift in the oxidant direction in pregnancies with COVID-19, which might support the view that ischemic processes play a role in the etiopathogenesis of this novel disease.
- Subjects
COVID-19 pandemic; HOMEOSTASIS; ALBUMINS; PREGNANT women; OXIDATIVE stress
- Publication
Turkish Journal of Obstetrics & Gynecology, 2022, Vol 19, Issue 1, p21
- ISSN
2149-9322
- Publication type
Article
- DOI
10.4274/tjod.galenos.2022.72929