We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk.
- Authors
West, Rebecca K.; Ravona‐Springer, Ramit; Sharvit‐Ginon, Inbal; Ganmore, Ithamar; Manzali, Sigalit; Tirosh, Amir; Golan, Sapir; Boccara, Ethel; Heymann, Anthony; Beeri, Michal Schnaider
- Abstract
Introduction: We examined relationships of body mass index (BMI) with cognition in middle‐aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods: Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long‐term trajectories of BMI with cognition. Results: Higher BMI was associated with worse language (P = .045). Interactions of BMI with parental history were significant for episodic memory (P = .023), language (p = .027), working memory (P = .006), global cognition (P = .008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory (P = .017), language (P = .013), working memory (P = .001), global cognition (P = .005), with stronger associations for maternal history. Discussion: Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.
- Publication
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021, Vol 13, Issue 1, p1
- ISSN
2352-8729
- Publication type
Article
- DOI
10.1002/dad2.12247