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- Title
481. EPIDEMIOLOGY of Seneca Valley Virus (SVV-001), a Novel Oncolytic Picornavirus for the Systemic Treatment of Patients with Solid Cancers with Neuroendocrine Features.
- Authors
Hales, Laura M.; Jones, Brian H.; Vasko, Ann-Jeanette; Knowles, Nick J.; Police, Seshidar R.; Hallenbeck, Paul L.
- Abstract
A virus was serendipitously isolated, presumably a contaminant of fetal bovine serum, and designated Seneca Valley Virus-001 (SVV-001). SVV-001 has oncolytic activity against adult tumors with neuroendocrine features but is not harmful to normal human cells. The complete genomic sequence of SVV-001 was determined and shown to have a typical picornavirus genomic structure. Twelve additional viruses have been isolated from pigs in various locations in the USA that appear to be related to SVV-001. The sequences of two genomic regions (VP1 and the 3' end) of six of the isolates were determined and analysis showed that all were closely related to SVV-001. The isolates and SVV-001 are also serologically related as antisera from one virus recognizes all isolates. Additionally, the selectivity of one of the isolates is identical to SVV-001. Phylogenetic analysis demonstrates that SVV-001 is most closely related to, but is clearly different, from members of the genus Cardiovirus; therefore, they should be classified as a new species (suggested name Seneca Valley virus) in a new genus (suggested name Senecovirus). Serological surveys revealed the presence of antibodies capable of neutralizing SVV-001 in pigs, cattle and mice, but not in humans. Attempts to infect pigs with SVV-001 and two of the related isolates failed to demonstrate any specific disease. SVV-001 has novel features which make it an attractive systemically deliverable oncolytic virus therapy.Molecular Therapy (2006) 13, S187–S187; doi: 10.1016/j.ymthe.2006.08.550
- Subjects
EPIDEMIOLOGY; PICORNAVIRUSES; TUMORS; CELLS; PHYLOGENY
- Publication
Molecular Therapy, 2006, Vol 13, pS187
- ISSN
1525-0016
- Publication type
Article
- DOI
10.1016/j.ymthe.2006.08.550