We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
E-cadherin might be a stage-dependent modulator in aggressiveness in pancreatic cancer cells.
- Authors
AYDEMİR ÇOBAN, Esra; TECİMEL, Didem; KAŞIKCI, Ezgi; BAYRAK, Ömer Faruk; ŞAHİN, Fikrettin
- Abstract
Pancreatic ductal adenocarcinoma (PDAC) pathology is known for its uncontrollable progress due to highly invasive characteristics and refractory behavior against existing chemotherapies. The aberrant expression of CDH1 (expresses the protein E-cadherin) is associated with increased overall survival in various cancers, however, E-cadherin expression in PDAC progression has remained elusive. We investigated the impact of exogenously elevated E-cadherin levels on the tumorigenicity of transduced low grade and metastatic PDAC cell lines, Panc-1 and AsPC-1, respectively. Constitutive expression of E-cadherin promoted a more hybrid E/M state in AsPC-1 cells, while it was associated with the acquisition of a more epithelial-like state in Panc1 cells. Our study suggests that E-cadherin may play differential roles in determining the metastatic characteristics of primary and metastatic pancreatic cancer cells.
- Subjects
PANCREATIC cancer; CANCER cells; METASTASIS; CELL lines; PATHOLOGY
- Publication
Turkish Journal of Biology, 2020, Vol 44, Issue 5, p230
- ISSN
1300-0152
- Publication type
Article
- DOI
10.3906/biy-1912-60