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- Title
外泌体在周围神经损伤进程中的效应.
- Authors
袁一鸣; 王 艳; 陈程程; 赵明月; 裴 飞
- Abstract
BACKGROUND: Due to intercellular communication functions and various biological characteristics, exosomes can deal with disease occurrence and development through multiple channels. It has great potential in the OBJECTIVE: To summarize the relevant role and mechanism of exosomes in the treatment of peripheral nerve injury, and provide a theoretical basis for clinical treatment of peripheral nerve injury and basic research. METHODS: The articles related to exosomes and nervous system injuries were searched in CNKI and PubMed databases from inception to October 2019. The keywords were “exosome, peripheral nervous injury, miRNA, Schwann cell, inflammation, vessel regeneration” in Chinese and English, respectively. Sixty eligible articles were included for analysis. RESULTS AND CONCLUSION: The structure and function of exosomes are summarized, and it has great advantages as a diagnostic index and treatment plan for various diseases. Exosomes and their main effectors miRNAs, mRNAs and proteins cannot only reflect the pathophysiologic conditions of the derived cells, but also are important ways for intercellular communication and bioactive material transport. In the perspective of the pathways for the treatment of peripheral nerve injury (axon regeneration, regulation of inflammation, angiogenesis), exosomes contribute to the repair of peripheral nerve injury.
- Subjects
EXOSOMES; SCHWANN cells; PERIPHERAL nervous system; CELL communication; NERVOUS system; MICRORNA; AXONS
- Publication
Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2020, Vol 24, Issue 31, p5079
- ISSN
2095-4344
- Publication type
Article
- DOI
10.3969/j.issn.2095-4344.2093