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- Title
Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study.
- Authors
Ohri, Nitin; Dawson, Laura A.; Krishnan, Sunil; Jinsil Seong; Cheng, Jason C.; Sarin, Shiv K.; Kinkhabwala, Milan; Ahmed, Mansoor M.; Vikram, Bhadrasain; Coleman, C. Norman; Guha, Chandan; Seong, Jinsil
- Abstract
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide; its incidence is increasing in the United States. Depending on disease extent and underlying liver status, patients may be treated with local, locoregional, and/or systemic therapy. Recent data indicates that radiotherapy (RT) can play a meaningful role in the management of HCC. Here, we review published experiences using RT for HCC, including the use of radiosensitizers and stereotactic RT. We discuss methods for performing preclinical studies of RT for HCC and biomarkers of response. As a part of the HCC Working Group, an informal committee of the National Cancer Institute's Radiation Research Program, we suggest how RT should be implemented in the management of HCC and identify future directions for the study of RT in HCC.
- Subjects
LIVER cancer; CANCER-related mortality; CANCER radiotherapy; STEREOTACTIC radiotherapy; TUMOR treatment; RADIATION-sensitizing agents; COMBINED modality therapy; HEPATOCELLULAR carcinoma; IMMUNOTHERAPY; LIVER transplantation; LIVER tumors; RADIOSURGERY; THERAPEUTICS
- Publication
JNCI: Journal of the National Cancer Institute, 2016, Vol 108, Issue 9, p1
- ISSN
0027-8874
- Publication type
journal article
- DOI
10.1093/jnci/djw133