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- Title
Severe anti-D haemolytic disease of fetal and newborn in rhesus D negative primigravida.
- Authors
HASSAN, Mohd Nazri; IBERAHIM, Salfarina; ABDUL RAHMAN, Wan Suriana Wan; ZULKAFLI, Zefarina; BAHAR, Rosnah; RAMLI, Marini; NOOR, Noor Haslina MOHD; MUSTAFFA, Rapiaah
- Abstract
Introduction: Anti-D alloimmunisation may occur from the blood transfusion or fetomaternal haemorrhage which can lead to haemolytic disease of fetal and newborn (HDFN). The morbidity and mortality of HDFN related to anti-D is significantly reduced after introduction of anti-D prophylaxis and furthermore, anti-D HDFN in RhD negative primigravida is uncommonly seen. Case Report: A case of unusual severe HDFN due to anti-D alloimmunisation in undiagnosed RhD negative primigravida Malay woman is reported here. This case illustrates the possibility of an anamnestic response from previous unknown sensitisation event or the development of anti-D in mid trimester. The newborn expired due to hydrops fetalis and severe anaemia. Antenatally, the mother was identified as RhD positive and thus there was no antenatal antibody screening, antepartum anti-D prophylaxis or close fetal monitoring for HDFN. Discussion: The thorough antenatal ABO and RhD blood grouping with antibody screening is mandatory as part of prevention and early detection of HDFN especially due to anti-D alloimmunisation. Improper management of RhD negative women might lead to severe HDFN including in primigravida.
- Subjects
FETAL diseases; HYDROPS fetalis; BLOOD groups; FETAL monitoring; BLOOD transfusion
- Publication
Malaysian Journal of Pathology, 2019, Vol 41, Issue 1, p55
- ISSN
0126-8635
- Publication type
Article