We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Dynamics of Change in Total and Regional Body Composition After Gastric Bypass in Obese Patients.
- Authors
Ciangura, Cecile; Bouillot, Jean-Luc; Lloret-Linares, Celia; Poitou, Christine; Veyrie, Nicolas; Basdevant, Arnaud; Oppert, Jean-Michel
- Abstract
Little is known on patterns of change over time in body composition, especially lean body mass (LBM), during massive weight loss after Roux-en-Y gastric bypass (RYGB) in obese patients. We performed sequential measurements of total and regional body composition in patients after RYGB, and we compared a subsample of patients after surgery to a nonsurgical control group of similar age and body fatness. We used dual-energy X-ray absorptiometry (DXA) before and at 3, 6, and 12 months after RYGB in 42 obese women (before surgery: age 39.5 ± 11.6 years; BMI 44.6 ± 6.1 kg/m2; mean ± s.d.) and in 48 control obese women referred for nonsurgical weight management, before weight loss. During 1-year follow-up after RYGB, there was a continuous decrease in body weight (−36.0 ± 12.5 kg at 1 year), total fat mass (FM) (−26.0 ± 9.1 kg), as well as in trunk and appendicular FM. In contrast, the decrease in total LBM (−9.8 ± 4.8 kg at 1 year), as well as in trunk and appendicular LBM, plateaued after 3–6 months. Rates of loss in weight, FM, and LBM were highest during the first 3-month period after RYGB (6.4 ± 1.8, 4.1 ± 1.7, and 2.3 ± 1.2 kg/month, respectively), then decreased continuously for FM but plateaued for LBM. There was no evidence of a decrease in total, trunk, or appendicular LBM in weight-reduced subjects compared to the control group. In conclusion, follow-up of these obese women revealed a differential pattern of change in FM and LBM after RYGB. Despite an important loss in LBM, especially during the 3–6 months of initial period, LBM appears to be spared thereafter.
- Subjects
BODY composition; GASTRIC bypass; OVERWEIGHT persons; LEAN body mass; WEIGHT loss; PHYSIOLOGY
- Publication
Obesity (19307381), 2010, Vol 18, Issue 4, p760
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1038/oby.2009.348