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- Title
Prolonged Neuromuscular Block in a 74-Year- Old Patient.
- Authors
Branch, Allen; Rafacz, John; Boudreaux, Lisa
- Abstract
Pseudocholinesterase abnormalities are an inherited trait, which causes aberrant metabolism of certain ester-based drugs. This anomaly poses the greatest risk for patients undergoing anesthesia when providers use the muscle relaxant succinylcholine because of its characteristic short duration of action. This abnormal metabolism can necessitate prolonged intubation, for greater than 8 hours in some cases. Depending on the type of surgical facility, this aberration can pose difficulties with case management. With the growing trend for freestanding surgical centers, the stage is set for additional complications because these facili- ties are unable to accommodate prolonged intubation with mechanical ventilation. This case study examines a single case of pseudocholinesterase insufficiency, which necessitated hospital admission to the intensive care unit until adequate recovery was achieved. It is important to educate affected individuals, as they may require general anesthetics for future procedures in which succinylcholine might be administered for laryngoscopy.
- Subjects
MYONEURAL junction; ACETYLCHOLINESTERASE; CHOLINESTERASES; GENES; LAPAROSCOPIC surgery; GENETIC mutation; NEUROMUSCULAR blocking agents; NEUROMUSCULAR depolarizing agents; PHYSIOLOGY
- Publication
AANA Journal, 2011, Vol 79, Issue 4, p317
- ISSN
0094-6354
- Publication type
Article