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- Title
Heavy Cigarette Smokers in a Chinese Population Display a Compromised Permeability Barrier.
- Authors
Xin, Shujun; Ye, Li; Man, George; Lv, Chengzhi; Elias, Peter M.; Man, Mao-Qiang
- Abstract
Cigarette smoking is associated with various cutaneous disorders with defective permeability. Yet, whether cigarette smoking influences epidermal permeability barrier function is largely unknown. Here, we measured skin biophysical properties, including permeability barrier homeostasis, stratum corneum (SC) integrity, SC hydration, skin surface pH, and skin melanin/erythema index, in cigarette smokers. A total of 99 male volunteers were enrolled in this study. Smokers were categorized as light-to-moderate (<20 cigarettes/day) or heavy smokers (≥20 cigarettes/day). An MPA5 was used to measure SC hydration and skin melanin/erythema index on the dorsal hand, forehead, and cheek. Basal transepidermal water loss (TEWL) and barrier recovery rates were assessed on the forearm. A Skin-pH-Meter pH900 was used to measure skin surface pH. Our results showed that heavy cigarette smokers exhibited delayed barrier recovery after acute abrogation (1.02%±13.06 versus 16.48%±6.07), and barrier recovery rates correlated negatively with the number of daily cigarettes consumption (p=0.0087). Changes in biophysical parameters in cigarette smokers varied with body sites. In conclusion, heavy cigarette smokers display compromised permeability barrier homeostasis, which could contribute, in part, to the increased prevalence of certain cutaneous disorders characterized by defective permeability. Thus, improving epidermal permeability barrier should be considered for heavy cigarette smokers.
- Subjects
CHINESE people; EPIDERMIS; ERYTHEMA; HOMEOSTASIS; HYDROGEN-ion concentration; MELANINS; PERMEABILITY; PROBABILITY theory; REGRESSION analysis; RESEARCH funding; SKIN; SMOKING; STATISTICS; T-test (Statistics); WATER-electrolyte balance (Physiology); DATA analysis; DATA analysis software; DESCRIPTIVE statistics; KRUSKAL-Wallis Test; ONE-way analysis of variance
- Publication
BioMed Research International, 2016, Vol 2016, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2016/9704598