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- Title
CD155/TIGIT signalling plays a vital role in the regulation of bone marrow mesenchymal stem cell–induced natural killer–cell exhaustion in multiple myeloma.
- Authors
Liu, Zhao‐Yun; Deng, Ling; Jia, Yue; Liu, Hui; Ding, Kai; Wang, Wei; Zhang, Hongkai; Fu, Rong
- Abstract
They found that NK cells were increased during MM early stages and correlated with the expression of chemokine receptors.9 Their study revealed an overall change of immune cells in MM, but they did not focus on the inhibitory receptors on NK cells. CD155/TIGIT signalling plays a vital role in the regulation of bone marrow mesenchymal stem cell-induced natural killer-cell exhaustion in multiple myeloma Dear Editor, T-cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT) is a potential immune checkpoint for natural killer (NK)-cell exhaustion in multiple myeloma (MM), and its ligand, CD155 on bone marrow mesenchymal stem cells (BMSCs), is highly expressed in newly diagnosed MM (NDMM) but expressed at extremely low levels on myeloma cells. The expression of activated and functional molecules in TIGIT+NK cells was lower than that on TIGIT-NK cells, whereas those on CD226+NK cells were elevated.
- Subjects
BONE marrow; MULTIPLE myeloma; STEM cell niches; CELL anatomy; KILLER cells; HEMATOPOIETIC stem cells; CALRETININ
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 7, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.861