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- Title
Emerging trends in nanomedicine for topical delivery in skin disorders: Current and translational approaches.
- Authors
Pandey, Parijat; Satija, Saurabh; Wadhwa, Ridhima; Mehta, Meenu; Purohit, Deepika; Gupta, Gaurav; Prasher, Parteek; Chellappan, Dinesh K.; Awasthi, Rajendra; Dureja, Harish; Dua, Kamal
- Abstract
Abbreviations API active pharmaceutical ingredient BUDHP- -CD budesonide inclusion complex CNT carbon nanotube CPA cyproterone acetate DSS dextran sodium sulfate EPR enhanced permeation and retention IBD inflammatory bowel disease MIC minimum inhibitory concentration MPO myeloperoxidase NLC nanostructured lipid carriers NSAIDs nonsteroidal anti-inflammatory drugs PAMAM polyamidoamine PCL poly-( -caprolactone) PEG poly-ethylene glycol PEO poly-ethylene oxide PGA poly-(glycolic acid) PL poloxamers PLA poly- l -lactide PLGA poly-(lactide-co-glycolide) PVA polyvinyl acetate PTX-CTs paclitaxel-enclosed cell-penetrating peptide altered transfersomes SC stratum corneum SLN solid-lipid nanoparticles SPG Schizophyllan INTRODUCTION A drug can be administered topically in a localized manner anywhere in the body through various routes including ophthalmic, rectal, vaginal, and skin.[1] Being the largest organ of the human body, the skin performs various functions including protection from the external environment, it serves as the first line of defense against the entry of microorganisms and chemicals, and provides a barrier to the loss of salts and fluids which helps in regulating body temperature.[2] It performs numerous indispensable capacities, including insurance against outside physical, substance and biologic attackers, just as avoidance of overabundance water loss from the body and a role in thermoregulation. For designing a drug delivery system for skin, it is very important to understand the anatomy of the skin anatomy as it influences the choice of drug as well as the method of drug delivery.[15] Skin absorption mechanism of topical drug delivery systems is shown in Figure.
- Subjects
TARGETED drug delivery; DISEASES; DRUG delivery systems; SKIN; SKIN permeability; DRUG solubility; ACETONEMIA
- Publication
Dermatologic Therapy, 2020, Vol 33, Issue 3, p1
- ISSN
1396-0296
- Publication type
Article
- DOI
10.1111/dth.13292