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- Title
NF-κB inhibitory, antimicrobial and antiproliferative potentials of compounds from Hawaiian fungus Aspergillus polyporicola FS910.
- Authors
Wang, Cong; Zaman, K. H. Ahammad uz; Sarotti, Ariel M.; Wu, Xiaohua; Zheng, Shao-Liang; Cao, Shugeng
- Abstract
Bioassay-guided experimental design and chromatographic analysis led to the isolation and identification of ten compounds (1–10) including two unusual sulfur-containing curvularin macrolides (1 and 2) from a Hawaiian fungal strain Aspergillus polyporicola FS910. Compounds 1 and 2 are rare curvularin macrolides each with a five-membered cyclic sulfur-containing moiety. The structures of the compounds were identified by HRESIMS, NMR spectroscopy, X-ray crystallography, ECD and DFT energy calculation, as well as comparing with previous literatures. Compounds 4, 6 and 8 were active against TNF-α-induced NF-κB inhibitory activity with IC50 values of 26.45, 5.41 and 15.8 µM, respectively. Compounds 3 and 5–8 exhibited anti-proliferative activity against HT1080, T46D, and A2780S cell lines, with IC50 values ranging from 2.48 to 29.17 μM. Additionally, Compound 3 showed promising antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), Bacillus subtilis, Escherichia coli and Candida albicans. Moreover, when tested in combination with antibiotic adjuvant disulfiram [4 µg/mL], compounds 4, 5 and 10 also displayed significant antibacterial activity against S. aureus.
- Subjects
QUINAZOLINONES; ASPERGILLUS; METHICILLIN-resistant staphylococcus aureus; X-ray crystallography; CHROMATOGRAPHIC analysis; NUCLEAR magnetic resonance spectroscopy; SULFUR compounds
- Publication
3 Biotech, 2021, Vol 11, Issue 8, p1
- ISSN
2190-572X
- Publication type
Article
- DOI
10.1007/s13205-021-02877-7