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- Title
Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing.
- Authors
Soon Hee Kim; Yeung Kyu Yeon; Jung Min Lee; Janet Ren Chao; Young Jin Lee; Ye Been Seo; Sultan, Md. Tipu; Ok Joo Lee; Ji Seung Lee; Sung-il Yoon; In-Sun Hong; Gilson Khang; Sang Jin Lee; Yoo, James J.; Chan Hum Park
- Abstract
Although three-dimensional (3D) bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant engineering challenges to overcome, including lack of bioink with biocompatibility and printability. Here, we show a bioink created from silk fibroin (SF) for digital light processing (DLP) 3D bioprinting in tissue engineering applications. The SF-based bioink (Sil-MA) was produced by a methacrylation process using glycidyl methacrylate (GMA) during the fabrication of SF solution. The mechanical and rheological properties of Sil-MA hydrogel proved to be outstanding in experimental testing and can be modulated by varying the Sil-MA contents. This Sil-MA bioink allowed us to build highly complex organ structures, including the heart, vessel, brain, trachea and ear with excellent structural stability and reliable biocompatibility. Sil-MA bioink is well-suited for use in DLP printing process and could be applied to tissue and organ engineering depending on the specific biological requirements.
- Publication
Nature Communications, 2018, Vol 9, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-018-03759-y