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- Title
Adverse Factors of Treatment Response and Overall Survival in Pediatric and Adult Patients with Pineoblastoma.
- Authors
Huo, Xu-Lei; Wang, Bo; Zhang, Gui-Jun; Ma, Jun-Peng; Wang, Liang; Zhang, Li-Wei; Xu, Xiao-Ying; Li, Xiao-Jie; Li, Huan; Li, Da; Zhang, Jun-Ting; Wu, Zhen
- Abstract
aim of this study was to describe the independent prognostic factors and treatment strategies for overall survival in pediatric and adult patients. Methods: Sixty-four patients were surgically treated between January 2012 and December 2018. Results: The series included 37 (57.8%) males and 27 (42.2%) females. Gross total resection was achieved in 41 (64.1%) cases, and the 1-, 3-, and 5-year rates of overall survival were 86.3, 52.3, and 36.6%, respectively. In the pediatric group (n=42), 28 patients (66.7%) were male, with the median, and the mean age was 4 and 6.2± 4.7 years, respectively. After a median follow-up of 25.0 months, twenty-six patients (61.9%) died, and the 1-, 3-, and 5-year rates of overall survival were 84.9, 46.4, and 26.7%, respectively. Postoperative radiotherapy (p=0.058) and postoperative chemotherapy (p=0.183) had a positive influence on the increased overall survival. Meanwhile, postoperative radiotherapy combined with chemotherapy following surgery had a positive impact on overall survival (p=0.174, Log rank). In the adult group, the mean overall survival was 67.3± 9.3 months (range, 0.8– 95.3 months), and the 1-, 3-, and 5-year rates of overall survival were 89.5, 64.4, and 64.4%, respectively. In this group, no statistical association was observed between clinical factors and outcomes. However, patients who received postoperative radiotherapy (60.7 vs 57.6 month, mean survival; p=0.510, Log rank) or chemotherapy (63.0 vs 59.9 month, mean survival; p=0.404, Log rank) had better survival rates compared with those who declined. Conclusion: In the pediatric group, surgery with postoperative radiotherapy and chemotherapy was a favorable factor for overall survival. In the adult group, a positive trend in overall survival was found when patients received radiation and/or chemotherapy following surgery.
- Subjects
STATISTICAL association
- Publication
Cancer Management & Research, 2020, Vol 12, p7343
- ISSN
1179-1322
- Publication type
Article
- DOI
10.2147/CMAR.S258476