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- Title
Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus.
- Authors
Yurchenko, Anton N.; Trinh, Phan Thi Hoai; Girich (Ivanets), Elena V.; Smetanina, Olga F.; Rasin, Anton B.; Popov, Roman S.; Dyshlovoy, Sergey A.; von Amsberg, Gunhild; Menchinskaya, Ekaterina S.; Thanh Van, Tran Thi; Afiyatullov, Shamil Sh.
- Abstract
Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The structures of compounds 1–10 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher's method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells.
- Subjects
POLYKETIDES; MARINE fungi; ASPERGILLUS; METABOLITES; COUPLING constants; PROSTATE cancer
- Publication
Marine Drugs, 2019, Vol 17, Issue 10, p579
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md17100579