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- Title
Removal of blood amyloid-β with hemodialysis reduced brain amyloid-β, confirmed by brain imaging: a case report.
- Authors
Kitaguchi, Nobuya; Kato, Takashi; Matsunaga, Shinji; Hirano, Kyoko; Iwata, Kaori; Kawaguchi, Kazunori; Fujita, Kiyoshi; Takechi, Hajime; Hasegawa, Midori; Yuzawa, Yukio; Ito, Kengo
- Abstract
The accumulation of amyloid-β protein (Aβ) in the brain signifies a major pathological change of Alzheimer's disease (AD). Extracorporeal blood Aβ removal system (E-BARS) has been under development as a tool for enhancing the clearance of Aβ from the brain. Previously, we revealed that dialyzers remove blood Aβs effectively, evoking substantial Aβ influx into the blood during hemodialysis sessions as one form of blood Aβ removal by E-BARS, and that postmortem brains of hemodialysis patients exhibited lower Aβ accumulation. Here, we present a case report of a 77-year-old male patient with end-stage renal failure whose Aβ accumulation in the brain declined by initiating and continuing hemodialysis for 6 months. This report suggests that blood Aβ removal by E-BARS could be an effective therapeutic method for AD.
- Subjects
BRAIN imaging; SKULL; KIDNEY failure; HEMODIALYSIS
- Publication
Neuropsychiatric Disease & Treatment, 2018, Vol 14, p2931
- ISSN
1176-6328
- Publication type
Article
- DOI
10.2147/NDT.S186118