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- Title
Reversal of olanzapine-induced weight gain in a patient with schizophrenia by switching to asenapine: a case report.
- Authors
Kosuke Okazaki; Kazuhiko Yamamuro; Toshifumi Kishimoto
- Abstract
Aims: Antipsychotics are effective for treating schizophrenia, but atypical antipsychotics can cause several adverse side effects including weight gain, hyperprolactinemia, and extrapyramidal symptoms. Moreover, weight gain increases the risk of metabolic diseases. Methods: We treated a case of olanzapine-induced weight gain in a 41-year-old man with schizophrenia by switching his medication from olanzapine to asenapine. Results: The weight gain improved after switching the medication, from 80.3 to 75.0 kg, a weight loss of 6.6%, and there was no significant worsening of psychological symptoms or other adverse effects. Conclusions: Asenapine might be effective for treating patients with schizophrenia who experience olanzapine-induced weight gain.
- Subjects
SCHIZOPHRENIA; WEIGHT gain; HYPERPROLACTINEMIA; METABOLIC disorders; OLANZAPINE; WEIGHT loss; THERAPEUTICS; CASE studies
- Publication
Neuropsychiatric Disease & Treatment, 2017, Vol 13, p2837
- ISSN
1176-6328
- Publication type
Case Study
- DOI
10.2147/NDT.S148616