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- Title
Subthreshold Photocoagulation Using Endpoint Management in the PASCAL® System for Diffuse Diabetic Macular Edema.
- Authors
Hamada, Masafumi; Ohkoshi, Kishiko; Inagaki, Keiji; Ebihara, Nobuyuki; Murakami, Akira
- Abstract
We evaluated subthreshold photocoagulation using endpoint management (EPM) for the treatment of diabetic macular edema (DME). The study enrolled 10 eyes from 10 patients (6 men and 4 women) with DME. The entry criteria included central macular thickness (CMT) ≥ 300 <italic>μ</italic>m and decimal visual acuity (VA) ≤ 0.5. The primary endpoints were VA (logMAR) and CMT at 6 months follow-up. Secondary endpoints included fundus autofluorescence, macular volume (MV), and macular sensitivity (MS). We used the PASCAL Streamline Yellow® (wavelength, 577 nm) system to perform grid pattern laser photocoagulation at 50% of the threshold (size, 100 <italic>μ</italic>m; duration, 0.015 s; spacing, 0.5; and energy, 4.5–7.8 mJ). At 6 months posttreatment, CMT was significantly decreased, while there were no significant changes in macular sensitivity, mean BCVA (logMAR), or macular volume. Autofluorescence imaging revealed no changes after treatment in 6 of 10 eyes. No eyes exhibited subjective symptoms of scotoma after photocoagulation. Optical coherence tomography showed the complete resolution of macular edema in 4 eyes (40%) after a single treatment; MS was increased in all 4 of these eyes at 6 months posttreatment. In conclusion, subthreshold photocoagulation using EPM is safe and effective for DME treatment and preserves MS. This trial is registered with <ext-link>UMIN000012401</ext-link>.
- Subjects
TREATMENT effectiveness; CLINICAL trials; DIABETIC retinopathy; OPHTHALMIC surgery; MEDICAL lasers; PATIENTS; RETINAL degeneration; SURGERY; VISUAL acuity; OPTICAL coherence tomography
- Publication
Journal of Ophthalmology, 2018, p1
- ISSN
2090-004X
- Publication type
Article
- DOI
10.1155/2018/7465794