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- Title
The risk of breast cancer in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers without a first‐degree relative with breast cancer.
- Authors
and the Hereditary Breast Cancer Clinical Study Group; Metcalfe, K. A.; Senter, L.; Narod, S. A.; Eisen, A.; Sun, P.; Lubinski, J.; Gronwald, J.; Huzarski, T.; McCuaig, J.; Lynch, H. T.; Karlan, B.; Foulkes, W. D.; Singer, C. F.; Neuhausen, S. L.
- Abstract
The objective of this study was to estimate the lifetime risk of breast cancer in women with a <italic>BRCA1</italic> or <italic>BRCA2</italic> mutation with and without at least 1 first‐degree relative with breast cancer. A total of 2835 women with a <italic>BRCA1</italic> or <italic>BRCA2</italic> mutation were followed. Age‐ and gene‐specific breast cancer rates were calculated. The relative risks of breast cancer for subjects with a family history of breast cancer, compared to no family history were calculated. The mean age at baseline was 41.1 years, and they were followed for a mean of 6.0 years. The estimated penetrance of breast cancer to age 80 years was 60.8% for <italic>BRCA1</italic> and 63.1% for <italic>BRCA2</italic>. For all <italic>BRCA</italic> carriers, the penetrance of breast cancer to age 80 for those with no first‐degree relative with breast cancer was 60.4% and 63.3% for those with at least 1 first‐degree relative with breast cancer. The risk of breast cancer for <italic>BRCA</italic> carriers with no first‐degree relative with breast cancer is substantial, and as a result, clinical management for these women should be the same as those for women with an affected relative.
- Subjects
BRCA genes; BREAST cancer; GENEALOGY; GENETIC mutation; BREAST cancer risk factors
- Publication
Clinical Genetics, 2018, Vol 93, Issue 5, p1063
- ISSN
0009-9163
- Publication type
Article
- DOI
10.1111/cge.13191