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- Title
Phenotypic and genotypic characterization of Chinese children diagnosed with tuberous sclerosis complex.
- Authors
Yang, G.; Shi, Z.N.; Meng, Y.; Shi, X.Y.; Pang, L.Y.; Ma, S.F.; Zhang, M.N.; Wang, Y.Y.; Zou, L.P.
- Abstract
We investigated the clinical phenotypes and genetic mutations in Chinese children diagnosed with tuberous sclerosis complex ( TSC). Sequencing of TSC1 and TSC2 genes was performed in 117 children with TSC and their parents. Association of TSC gene mutations with clinical manifestations was investigated. All gene mutations were heterozygous including in 16 patients (13.7%) with mutations in TSC1 gene and 101 patients (86.3%) with mutations in TSC2 gene. Among the 16 patients with TSC1 gene mutations, 15 different types of mutations were found, which included 5 novel mutations; all patients had skin manifestations and epilepsy. Among the 101 patients with TSC2 mutations, 85 different types of mutations were found, which included 25 novel mutations; 97 patients (96.0%) had skin manifestations; 97 (96.0%) had epilepsy; 74 (73.3%) had intellectual disability and 25 patients (24.8%) were autistic. The clinical phenotype of the 14 children with familial TSC was more severe than that of their parents.
- Subjects
PHENOTYPES; GENOTYPES; TUBEROUS sclerosis; INTELLECTUAL disabilities; GENETIC mutation
- Publication
Clinical Genetics, 2017, Vol 91, Issue 5, p764
- ISSN
0009-9163
- Publication type
Article
- DOI
10.1111/cge.12920