We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The influence of propolis nanoparticles on dermal fibroblasts migration: premises for development of propolis-based collagen dermal patches.
- Authors
Pasca, P. M.; Cavalu, S.
- Abstract
Knowing the biological and pharmacological properties of propolis, the first goal of our study was to prepare and characterize a propolis nano-formulation (NPs) in order to be used for wound healing applications. The ability of propolis NPs to stimulate the migration of dermal fibroblasts in vitro was assessed by scratch test assay. The concentration of 200 µg/mL propolis NPs was found to have similar effect as the positive control. The second goal was to prepare a propolis-collagen membrane and to investigate the morphological and nanoindentation properties by AFM. The ultrastructure network of collagen fibrils was not affected by incorporation of propolis NPs, showing a nano-porous structure, favorable for soft tissue regeneration applications. Enzymatic degradation assay indicated a reduced degradation rate upon incorporation of propolis NPs in collagen matrix.
- Subjects
PROPOLIS; FIBROBLASTS; COLLAGEN; WOUND healing; NANOPARTICLES
- Publication
Digest Journal of Nanomaterials & Biostructures (DJNB), 2021, Vol 16, Issue 3, p929
- ISSN
1842-3582
- Publication type
Article
- DOI
10.15251/djnb.2021.163.929