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- Title
Decreased Glucagon-Like Peptide-1 Receptor Immunoreactivity in the Dentate Granule Cell Layer from Adult in the Gerbil Hippocampus.
- Authors
Choong Hyun Lee; Ki-Yeon Yoo; Pan Dong Ryu; Joon Ha Park; Jung Hoon Choi; Sookon Kim; In Koo Hwang; Young-Myeong Kim; Moo-Ho Won
- Abstract
In this study, we investigated age-related changes in glucagon-like peptide-1 receptor (GLP-1R) immunoreactivity and its protein levels in the gerbil hippocampus during normal aging. In the postnatal month 3 (PM 3) group, GLP-1R immunoreaction was well observed in neurons, especially pyramidal and non-pyramidal cells in the hippocampus proper, and granule and polymorphic cells in the dentate gyrus. In the hippocampus proper, GLP-1R immunoreactivity in neurons was maintained until PM 24. In the dentate gyrus, however, GLP-1R immunoreactivity in granule cells, not polymorphic cells, was hardly detected from PM 6. Western blot analysis also showed that age-dependent change patterns in GLP-1R protein levels in the gerbil hippocampus were similar to the immunohistochemical changes. These results indicate that GLP-1R immunoreactivity was markedly decreased in dentate granule cells from PM 6, showing that GLP-1R immunoreactivity and its protein levels were decreased in the adult and aged gerbil hippocampus.
- Subjects
GLUCAGON-like peptide 1; AGING; HIPPOCAMPUS (Brain); GERBILS; DENTATE gyrus; NERVOUS system
- Publication
Cellular & Molecular Neurobiology, 2011, Vol 31, Issue 3, p345
- ISSN
0272-4340
- Publication type
Article
- DOI
10.1007/s10571-010-9632-7