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Stress-Kinase Regulation of TASK-1 and TASK-3.
Published in:
Cellular Physiology & Biochemistry (Karger AG), 2017, v. 44, n. 3, p. 1024, doi. 10.1159/000485402
By:
- Rinné, Susanne;
- Kiper, Aytug K.;
- Schmidt, Constanze;
- Ortiz-Bonnin, Beatriz;
- Zwiener, Simone;
- Seebohm, Guiscard;
- Decher, Niels
Publication type:
Article
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06832-1
By:
- Matschke, Lina A.;
- Komadowski, Marlene A.;
- Stöhr, Annette;
- Lee, Bolam;
- Henrich, Martin T.;
- Griesbach, Markus;
- Rinné, Susanne;
- Geibl, Fanni F.;
- Chiu, Wei-Hua;
- Koprich, James B.;
- Brotchie, Jonathan M.;
- Kiper, Aytug K.;
- Dolga, Amalia M.;
- Oertel, Wolfgang H.;
- Decher, Niels
Publication type:
Article
A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels.
Published in:
Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.855792
By:
- Valdés-Jiménez, Alejandro;
- Jiménez-González, Daniel;
- Kiper, Aytug K.;
- Rinné, Susanne;
- Decher, Niels;
- González, Wendy;
- Reyes-Parada, Miguel;
- Núñez-Vivanco, Gabriel
Publication type:
Article
Sodium permeable and 'hypersensitive' TREK-1 channels cause ventricular tachycardia.
Published in:
EMBO Molecular Medicine, 2017, v. 9, n. 4, p. 403, doi. 10.15252/emmm.201606690
By:
- Decher, Niels;
- Ortiz‐Bonnin, Beatriz;
- Friedrich, Corinna;
- Schewe, Marcus;
- Kiper, Aytug K;
- Rinné, Susanne;
- Seemann, Gunnar;
- Peyronnet, Rémi;
- Zumhagen, Sven;
- Bustos, Daniel;
- Kockskämper, Jens;
- Kohl, Peter;
- Just, Steffen;
- González, Wendy;
- Baukrowitz, Thomas;
- Stallmeyer, Birgit;
- Schulze‐Bahr, Eric
Publication type:
Article
Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.
Published in:
EMBO Molecular Medicine, 2014, v. 6, n. 7, p. 937, doi. 10.15252/emmm.201303783
By:
- Friedrich, Corinna;
- Rinné, Susanne;
- Zumhagen, Sven;
- Kiper, Aytug K;
- Silbernagel, Nicole;
- Netter, Michael F;
- Stallmeyer, Birgit;
- Schulze‐Bahr, Eric;
- Decher, Niels
Publication type:
Article
Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 16, p. 4014, doi. 10.3390/ijms20164014
By:
- Ramírez, David;
- Concha, Guierdy;
- Arévalo, Bárbara;
- Prent-Peñaloza, Luis;
- Zúñiga, Leandro;
- Kiper, Aytug K.;
- Rinné, Susanne;
- Reyes-Parada, Miguel;
- Decher, Niels;
- González, Wendy;
- Caballero, Julio
Publication type:
Article
Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 9, p. 2252, doi. 10.3390/ijms20092252
By:
- Ramírez, David;
- Bedoya, Mauricio;
- Kiper, Aytug K.;
- Rinné, Susanne;
- Morales-Navarro, Samuel;
- Hernández-Rodríguez, Erix W.;
- Sepúlveda, Francisco V.;
- Decher, Niels;
- González, Wendy
Publication type:
Article
Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels.
Published in:
Scientific Reports, 2016, p. 19492, doi. 10.1038/srep19492
By:
- Goldstein, Matthias;
- Rinné, Susanne;
- Kiper, Aytug K.;
- Ramírez, David;
- Netter, Michael F.;
- Bustos, Daniel;
- Ortiz-Bonnin, Beatriz;
- González, Wendy;
- Decher, Niels
Publication type:
Article
The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.
Published in:
FASEB Journal, 2018, v. 32, n. 11, p. 6159, doi. 10.1096/fj.201800246R
By:
- Silbernagel, Nicole;
- Walecki, Magdalena;
- Schäfer, Martin K.-H.;
- Kessler, Mirjam;
- Zobeiri, Mehrnoush;
- Rinné, Susanne;
- Kiper, Aytug K.;
- Komadowski, Marlene A.;
- Vowinkel, Kirsty S.;
- Wemhöner, Konstantin;
- Fortmüller, Lisa;
- Schewe, Marcus;
- Dolga, Amalia M.;
- Scekic-Zahirovic, Jelena;
- Matschke, Lina A.;
- Culmsee, Carsten;
- Baukrowitz, Thomas;
- Monassier, Laurent;
- Ullrich, Nina D.;
- Dupuis, Luc
Publication type:
Article
Identification of a critical binding site for local anaesthetics in the side pockets of Kv 1 channels.
Published in:
2021
By:
- Kiper, Aytug K.;
- Bedoya, Mauricio;
- Stalke, Sarah;
- Marzian, Stefanie;
- Ramírez, David;
- Cruz, Alicia;
- Peraza, Diego A.;
- Vera‐Zambrano, Alba;
- Márquez Montesinos, José C. E.;
- Arévalo Ramos, Bárbara A.;
- Rinné, Susanne;
- Gonzalez, Teresa;
- Valenzuela, Carmen;
- Gonzalez, Wendy;
- Decher, Niels;
- de la Cruz, Alicia;
- Vera-Zambrano, Alba
Publication type:
journal article
Molecular Pharmacology of K2P Potassium Channels.
Published in:
Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2021, v. 55, p. 87, doi. 10.33594/000000339
By:
- Decher, Niels;
- Rinné, Susanne;
- Bedoya, Mauricio;
- Gonzalez, Wendy;
- Kiper, Aytug K.
Publication type:
Article
Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site.
Published in:
Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, v. 52, n. 5, p. 1223, doi. 10.33594/000000083
By:
- Wiedmann, Felix;
- Kiper, Aytug K.;
- Bedoya, Mauricio;
- Ratte, Antonius;
- Rinné, Susanne;
- Kraft, Manuel;
- Waibel, Maximilian;
- Anad, Priya;
- Wenzel, Wolfgang;
- González, Wendy;
- Katus, Hugo A.;
- Decher, Niels;
- Schmidt, Constanze
Publication type:
Article
5-(Indol-2-yl)pyrazolo[3,4- b ]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis.
Published in:
Molecules, 2021, v. 26, n. 13, p. 3897, doi. 10.3390/molecules26133897
By:
- Ramírez, David;
- Mejia-Gutierrez, Melissa;
- Insuasty, Braulio;
- Rinné, Susanne;
- Kiper, Aytug K.;
- Platzk, Magdalena;
- Müller, Thomas;
- Decher, Niels;
- Quiroga, Jairo;
- De-la-Torre, Pedro;
- González, Wendy
Publication type:
Article
Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05114-4
By:
- Schreiber, Julian Alexander;
- Derksen, Anastasia;
- Goerges, Gunnar;
- Schütte, Sven;
- Sörgel, Jasmin;
- Kiper, Aytug K.;
- Strutz-Seebohm, Nathalie;
- Ruck, Tobias;
- Meuth, Sven G.;
- Decher, Niels;
- Seebohm, Guiscard
Publication type:
Article
Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-51812-w
By:
- Neelsen, Lea C.;
- Riel, Elena B.;
- Rinné, Susanne;
- Schmid, Freya-Rebecca;
- Jürs, Björn C.;
- Bedoya, Mauricio;
- Langer, Jan P.;
- Eymsh, Bisher;
- Kiper, Aytug K.;
- Cordeiro, Sönke;
- Decher, Niels;
- Baukrowitz, Thomas;
- Schewe, Marcus
Publication type:
Article
Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-51288-8
By:
- Rinné, Susanne;
- Schick, Florian;
- Vowinkel, Kirsty;
- Schütte, Sven;
- Krasel, Cornelius;
- Kauferstein, Silke;
- Schäfer, Martin K.-H.;
- Kiper, Aytug K.;
- Müller, Thomas;
- Decher, Niels
Publication type:
Article
An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.
Published in:
Frontiers in Molecular Neuroscience, 2015, v. 8, p. 1, doi. 10.3389/fnmol.2015.00063
By:
- Wemhöner, Konstantin;
- Kanyshkova, Tatyana;
- Silbernagel, Nicole;
- Fernandez-Orth, Juncal;
- Bittner, Stefan;
- Kiper, Aytug K.;
- Rinné, Susanne;
- Netter, Michael F.;
- Meuth, Sven G.;
- Budde, Thomas;
- Decher, Niels;
- Barbuti, Andrea;
- Baram, Tallie Z.;
- Noam, Yoav
Publication type:
Article
Calcium Handling Remodeling Underlies Impaired Sympathetic Stress Response in Ventricular Myocardium from Cacna1c Haploinsufficient Rats.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 12, p. 9795, doi. 10.3390/ijms24129795
By:
- Fender, Hauke;
- Walter, Kim;
- Kiper, Aytug K.;
- Plačkić, Jelena;
- Kisko, Theresa M.;
- Braun, Moria D.;
- Schwarting, Rainer K. W.;
- Rohrbach, Susanne;
- Wöhr, Markus;
- Decher, Niels;
- Kockskämper, Jens
Publication type:
Article

Found: 18

Stress-Kinase Regulation of TASK-1 and TASK-3.

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.

A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels.

Sodium permeable and 'hypersensitive' TREK-1 channels cause ventricular tachycardia.

Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.

Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening.

Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine.

Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels.

The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.

Identification of a critical binding site for local anaesthetics in the side pockets of K<sub>v</sub> 1 channels.

Molecular Pharmacology of K<sub>2P</sub> Potassium Channels.

Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site.

5-(Indol-2-yl)pyrazolo[3,4- b ]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis.

Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter.

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K<sub>2P</sub> channel TALK-2.

Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence.

An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.

Calcium Handling Remodeling Underlies Impaired Sympathetic Stress Response in Ventricular Myocardium from Cacna1c Haploinsufficient Rats.