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- Title
Inositol 1,4,5-Trisphosphate Receptor Subtype-Specific Regulation of Calcium Oscillations.
- Authors
Zhang, Songbai; Fritz, Nicolas; Ibarra, Cristian; Uhlén, Per
- Abstract
Oscillatory fluctuations in the cytosolic concentration of free calcium ions (Ca) are considered a ubiquitous mechanism for controlling multiple cellular processes. Inositol 1,4,5-trisphosphate (IP) receptors (IPR) are intracellular Ca release channels that mediate Ca release from endoplasmic reticulum (ER) Ca stores. The three IPR subtypes described so far exhibit differential structural, biophysical, and biochemical properties. Subtype specific regulation of IPR by the endogenous modulators IP, Ca, protein kinases and associated proteins have been thoroughly examined. In this article we will review the contribution of each IPR subtype in shaping cytosolic Ca oscillations.
- Subjects
INOSITOL; PHOSPHATES; CELLULAR signal transduction; CALCIUM ions; PROTEIN kinases; ENDOPLASMIC reticulum; CALCIUM channels
- Publication
Neurochemical Research, 2011, Vol 36, Issue 7, p1175
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-011-0457-7