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- Title
Lysosomal degradation of intracellular nucleic acids--multiple autophagic pathways.
- Authors
Yuuki Fujiwara; Keiji Wada; Tomohiro Kabuta
- Abstract
Cell metabolism can be considered as a process of serial construction and destruction of cellular components, both of which must be regulated accurately. In eukaryotic cells, a variety of cellular components are actively delivered into lysosomes/vacuoles, specialized compartments for hydrolysis of macromolecules. Such processes of 'self-eating' are called autophagy. Despite a wide variety of lysosomal/vacuolar hydrolases, much of the interest has been focused on the proteolytic functions of autophagy and less attention has been devoted to the degradation of other macromolecules such as nucleic acids. In this review, we focus on delivery and degradation of endogenous nucleic acids by autophagic systems, and discuss their molecular mechanisms and physiological/pathophysiological roles.
- Subjects
LYSOSOMES; NUCLEIC acids; AUTOPHAGY; CELL metabolism; HYDROLASES
- Publication
Journal of Biochemistry, 2017, Vol 161, Issue 2, p145
- ISSN
0021-924X
- Publication type
Article
- DOI
10.1093/jb/mvw085