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- Title
High expression of heat shock protein 105 predicts a favorable prognosis for patients with urinary bladder cancer treated with radical cystectomy.
- Authors
TAKETO KAWAI; YUTAKA ENOMOTO; TEPPEI MORIKAWA; HIROKAZU MATSUSHITA; HARUKI KUME; MASASHI FUKAYAMA; HIROTSUGU YAMAGUCHI; KAZUHIRO KAKIMI; YUKIO HOMMA
- Abstract
Heat shock protein 105 (Hsp105) is one of the cancer/testis antigens, which is overexpressed in a variety of cancer cells, including urinary bladder cancer, and has been investigated as a target molecule for immunotherapy due to its immunogenicity. In this study, we assessed the expression of Hsp105 in primary bladder cancer samples from 84 patients treated with radical cystectomy, using immunohistochemical analysis, and investigated its correlation with clinicopathological characteristics and cancer-specific survival. The immunoreactivity of Hsp105 expression was evaluated as a score of 0 3, according to the intensity of the signal. The Hsp105 expression was high (score 2 or 3) in 31 cases and low (score 0or1) in 53cases; however, it was not significantly correlated with age, nuclear grade, pathological tumor stage and previous intravesical Bacillus Calmette-Guérin immunotherapy. Female gender, lymphovascular invasion and lymph node metastasis were associated with low Hsp105 scores, although the differences were not statistically significant (P=0.071, 0.061 and 0.175, respectively). However, a high Hsp105 score was significantly associated with a favorable prognosis (P=0.017) and was identified as an independent prognostic factor by multivariate analysis (P=0.032; hazard ratio, 2.34). These findings suggested that the expression of Hsp105 may be a novel indicator of a favorable prognosis in bladder cancer.
- Subjects
HEAT shock proteins; IMMUNOHISTOCHEMISTRY; BLADDER cancer patients; BLADDER cancer; BLADDER cancer treatment; CYSTECTOMY; PROGNOSIS
- Publication
Molecular & Clinical Oncology, 2014, Vol 2, Issue 1, p38
- ISSN
2049-9450
- Publication type
Article
- DOI
10.3892/mco.2013.203