We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Limited T-Cell Receptor V Gene Usage in Inclusion Body Myositis.
- Authors
Fyhr, I.-M.; Moslemi, A.-R.; Tarkowski, A.; Lindberg, C.; Oldfors, Anders
- Abstract
Inclusion body myositis (IBM) is a chronic, progressive inflammatory myopathy. The inflammatory infiltrates are dominated by T cells, which frequently invade muscle fibres. The present study was performed lo characterize the usage of the variable (V) segment of the T-cell receptor of muscle infiltrating cells in IBM. Using the reverse transcriptase polymerase chain reaction (RT-PCR) technique the authors analysed the expression of 22 Vα and 24 Vβ families in muscle tissue from six patients with IBM displaying intense inflammatory cell infiltration. The following Vα/Vβ families appeared in at least 50% of the patients: Vα1, 5, 7, 15, 16, 17, 20, 21, 22 and Vβ3, 5.2, 8, 12, 14, 22. In all patients Vα7, 16 and Vβ8 were expressed in muscle tissue. Furthermore, in two of the patients peripheral blood lymphocytes (PBL) were investigated in parallel. There was a restricted usage of Vα and Vβ families in muscle in comparison to PBL, indicating a selective homing or local proliferation of T lymphocytes in the Inflammatory lesions in IBM.
- Subjects
T cells; LYMPHOCYTES; CELL receptors; MYOSITIS; INFLAMMATION
- Publication
Scandinavian Journal of Immunology, 1996, Vol 43, Issue 1, p109
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.1996.d01-10.x