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- Title
Raman spectrum: A potential biomarker for embryo assessment during in vitro fertilization.
- Authors
JIAYI DING; TIAN XU; XIAOFANG TAN; HUA JIN; JUN SHAO; HAIBO LI
- Abstract
The aim of the study was to investigate whether Raman spectrum is consistent with the morphological scoring of the embryo of day 3 during in vitro fertilization (IVF). The spent culture media of embryo of day 3 from 10 patients were collected and analyzed. The samples were analyzed using Raman spectroscopy and graded according to the standard embryo scoring system simultaneously. Data showed that the Raman spectra obtained from the droplet of media were useful, as they can act as the characteristic signature for protein and amino acids. The Raman biospectroscopybased metabonomics profiling of spent media was consistent with the result of conventional morphological evaluation. In conclusion, this technology offers great potential for the development of tools allowing rapid non-invasive assessment of the quality of embryo of day 3 during IVF.
- Subjects
RAMAN spectroscopy; FERTILIZATION (Biology); EMBRYOS; AMINO acids; CULTURE media (Biology)
- Publication
Experimental & Therapeutic Medicine, 2017, Vol 13, Issue 5, p1789
- ISSN
1792-0981
- Publication type
Article
- DOI
10.3892/etm.2017.4160