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- Title
Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia.
- Authors
Morris, Emma C.; Harrison, Georgina; Bailey, Clifford C.; Hann, Ian M.; Hill, Frank G.; Gibson, Brenda E. S.; Richards, Susan; Webb, David K. H.
- Abstract
Summary. The Medical Research Council acute lymphoblastic leukaemia trials (UKALL X and XI) recruited 3702 children with ALL between January 1985 and March 1997. Seventy-nine children had central nervous system (CNS) involvement in their first two relapses. Fourteen children survived at a median follow-up of 22 months from second relapse; seven (9%) in third remission, two in later remissions and five with disease. Factors predictive of survival from second relapse were site (isolated CNS was better than combined CNS, P = 0·02) and time from diagnosis to second CNS relapse (longer time was better, P = 0·004). Prognosis after second CNS relapse is extremely poor, and palliative therapy is appropriate.
- Subjects
LYMPHOBLASTIC leukemia in children; CENTRAL nervous system cancer; CANCER relapse; PROGNOSIS
- Publication
British Journal of Haematology, 2003, Vol 120, Issue 5, p787
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2003.04158.x