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- Title
Cytogenetic heterogeneity of acute myeloid leukaemia (AML) with trilineage dysplasia: Japan Adult Leukaemia Study Group-AML 92 study.
- Authors
Miyazaki, Yasushi; Kuriyama, Kazutaka; Miyawaki, Shuichi; Ohtake, Shigeki; Sakamaki, Hisashi; Matsuo, Tatsuki; Emi, Nobuhiko; Kobayashi, Tohru; Matsushima, Takafumi; Shinagawa, Katsuji; Ohno, Ryuzo; Tomonaga, Masao
- Abstract
Summary. Acute myeloid leukaemia (AML) with trilineage dysplasia (AML/TLD) is de novo AML recognized by the morphological dysplasia of three mature cell lines in the presence of leukaemic blasts. We studied the karyotypes of AML/TLD of patients with de novo AML, except for those with the French–American–British classification M3, who were enrolled onto the Japan Adult Leukaemia Study Group (JALSG)-AML 92 trial. Morphological and cytogenetic analyses were performed in 559 patients and TLD phenotype was found in 155 patients (27·7%). The 511 patients with informative morphological and cytogenetic data were classified into three groups according to karyotype: favourable, intermediate and adverse risk groups (92, 375 and 44 patients respectively). Normal karyotype was the most frequent as a total, and among both the non-TLD and TLD patients (164 patients 45·3% and 78 patients 52·7% respectively). All but one patient with AML/TLD was classified into the intermediate or adverse cytogenetic risk group. TLD phenotype was associated with lower remission rate and shorter overall survival but it did not influence disease-free survival. Although we did not find any specific cytogenetic abnormalities for AML/TLD, the rarity of favourable karyotypes among TLD patients indicates the biological difference between AML/TLD and AML/non-TLD.
- Subjects
THROMBOSIS; VON Willebrand factor; THROMBIN
- Publication
British Journal of Haematology, 2003, Vol 120, Issue 1, p56
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2003.03981.x