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- Title
Common expression of an unusual CD45 isoform on T cells from patients with large granular lymphocyte leukaemiaand autoimmune lymphoproliferative syndrome.
- Authors
Bleesing, Jack J. H.; Janik, John E.; Fleisher, Thomas A.
- Abstract
Summary. Patients with T-cell large granular lymphocyte (T-LGL) leukaemia and autoimmune lymphoproliferative syndrome (ALPS) share many features, including autoimmunity and an expansion of (cytotoxic) T cells, which in ALPS patients express an unusual (B220) isoform of CD45, corresponding to an altered O -glycosylation profile. Here we showed that T-LGL leukaemia cells also expressed this B220 isoform. We hypothesize that B220+ T cells constitute proliferating T cells that have become competent to undergo apoptosis, but that constitutive (ALPS) or functional (T-LGL) defects prevent this process. Altered O -glycosylation of the extracellular domains of CD45 may have consequences for this tyrosine phosphatase as a regulator of cell proliferation and survival.
- Subjects
LYMPHOCYTIC leukemia; LYMPHOPROLIFERATIVE disorders; T cells
- Publication
British Journal of Haematology, 2003, Vol 120, Issue 1, p93
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2003.04034.x