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- Title
COVID-19 in Renal Transplant Recipients -- A Single Center Experience from India.
- Authors
Jha, Pranaw Kumar; Shukla, Saurabh; Bansal, Dinesh; Bansal, Shyam Bihari; Sethi, Sidharth; Jain, Manish; Yadav, Dinesh Kumar; Gadde, Ashwini; Mahapatra, Amit Kumar; Sodhi, Puneet; Kher, Vijay
- Abstract
Introduction: The information on the clinical outcome of renal transplant recipients getting COVID-19 infection is sparse. The aim of this study is to report a single-center experience of renal transplant recipients with COVID-19 from India. Methods: This was a retrospective study of 23 consecutive renal transplant recipients with COVID-19 infection presenting to our center from May 2020 to August 2020. Clinical parameters, laboratory values, imaging characteristics, and outcome of the patients were collected and analyzed. Results: Median follow-up duration was 36 (range: 10--110) days. Median age of patients was 54 (23--70) years, and 87% were male. Median duration since transplant was 69 (range: 15--132) months. The most common presenting feature was fever (82.6%), followed by breathlessness (43.5%) and cough (30.4%). Hospitalization rate was 52.2%, while 34.8% required ICU care. Severe to critical disease was seen in 39.1% of patients, and 17.4% required mechanical ventilation. Patients with severe disease had a higher incidence of lymphopenia (P = 0.005) when compared to the ones with mild to moderate disease. Acute kidney injury was seen in 39.1% of patients, and 13% required dialysis. Mortality rate was 13% overall, and 25% in those hospitalized. Conclusion: Renal transplant recipients with COVID-19 have a poor outcome. Although not all of them need hospitalization, they should be monitored closely. Immunosuppression minimization is an important part of the treatment strategy.
- Subjects
INDIA; CHRONIC kidney failure; EVALUATION of medical care; INTENSIVE care units; COVID-19; FEVER; CHEST X rays; TIME; IMMUNOCOMPROMISED patients; KIDNEY transplantation; PATIENTS; RETROSPECTIVE studies; DISEASE incidence; DYSPNEA; ARTIFICIAL respiration; SEVERITY of illness index; LYMPHOPENIA; HOSPITAL care; CRITICAL care medicine; SYMPTOMS; DESCRIPTIVE statistics; COUGH; BLOOD testing; COMPUTED tomography; HEMODIALYSIS; TRANSPLANTATION of organs, tissues, etc.; LONGITUDINAL method; ACUTE kidney failure
- Publication
Indian Journal of Nephrology, 2022, Vol 32, Issue 5, p416
- ISSN
0971-4065
- Publication type
Article
- DOI
10.4103/ijn.IJN_479_20