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- Title
Effect of Flos carthami Extract and α<sub>1</sub>-Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis.
- Authors
San-Yuan Wu; Kee-Ming Man; Jui-Lung Shen; Huey-Yi Chen; Chiao-Hui Chang; Fuu-Jen Tsai; Wen-Tsong Hsieh; Winardi, Daniel; Yuan-Ju Lee; Kao-Sung Tsai; Yu-Ning Lin; Yung-Hsiang Chen; Wen-Chi Chen
- Abstract
Traditional Chinese medicine (TCM) has been proposed to prevent urolithiasis. In China, Flos carthami (FC, also known as Carthamus tinctorius) (Safflower; Chinese name: Hong Hua/ ) has been used to treat urological diseases for centuries. We previously performed a screening and confirmed the in vivo antilithic effect of FC extract. Here, ex vivo organ bath experiment was further performed to study the effect of FC extract on the inhibition of phenylepinephrine (PE) (10-410-3 M) ureteral peristalsis of porcine ureters with several α1-adrenergic antagonists (doxazosin, tamsulosin, and terazosin) as experimental controls. The results showed that doxazosin, tamsulosin, and terazosin dose (approximately 4.5 × 10-6- 4.5 × 10-1 μg/mL) dependently inhibited both 10-4 and 10-3 M PE-induced ureteral peristalsis. FC extract achieved 6.2% ± 10.1%, 21.8% ± 6.8%, and 24.0% ± 5.6% inhibitions of 10-4 M PE-induced peristalsis at doses of 5 × 103, 1 × 104, and 2 × 104 μg/mL, respectively, since FC extract was unable to completely inhibit PE-induced ureteral peristalsis, suggesting the antilithic effect of FC extract is related to mechanisms other than modulation of ureteral peristalsis.
- Subjects
ADRENERGIC alpha blockers; THERAPEUTIC use of plant extracts; URETER diseases; ANIMAL experimentation; BIOLOGICAL models; EXPERIMENTAL design; GASTROINTESTINAL motility; HERBAL medicine; CHINESE medicine; RESEARCH funding; SWINE; TRANSDUCERS; DATA analysis software; DESCRIPTIVE statistics; PREVENTION; THERAPEUTICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2014, Vol 2014, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2014/437803