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- Title
Consensus Summary of Aerosolized Antimicrobial Agents: Application of Guideline Criteria.
- Authors
Le, Jennifer; Ashley, Elizabeth Dodds; Neuhauser, Melinda M.; Brown, Jack; Gentry, Chris; Klepser, Michael E.; Marr, Ann Marie; Schiller, Daryl; Schwiesow, Joshua N.; Tice, Sally; VandenBussche, Heather L.; Wood, G. Christopher
- Abstract
Aerosolized delivery of antimicrobial agents is an attractive option for management of pulmonary infections, as this is an ideal method of providing high local drug concentrations while minimizing systemic exposure. With the paucity of consensus regarding the safety, efficacy, and means with which to use aerosolized antimicrobials, a task force was created by the Society of Infectious Diseases Pharmacists to critically review and evaluate the literature on the use of aerosolized antiinfective agents. This article summarizes key findings and statements for preventing or treating a variety of infectious diseases, including cystic fibrosis, bronchiecstasis, hospital-acquired pneumonia, fungal infections, nontuberculosis mycobacterial infection, and Pneumocystis jiroveci pneumonia. Our intention was to provide guidance for clinicians on the use of aerosolized antibiotics through evidence-based pharmacotherapy. Further research with well-designed clinical trials is necessary to elucidate the optimal dosage and duration of therapy and, of equal importance, to appreciate the true risks associated with the use of aerosolized delivery systems.
- Subjects
ANTI-infective agents; AEROSOL therapy; ANTIFUNGAL agents; AMINOGLYCOSIDES; COMMUNICABLE disease treatment; MEDICATION safety; EVIDENCE-based medicine; CYSTIC fibrosis
- Publication
Pharmacotherapy, 2010, Vol 30, Issue 6, p562
- ISSN
0277-0008
- Publication type
Article
- DOI
10.1592/phco.30.6.562