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- Title
Neuroprotective effects of Tacca chantrieri Andre against lipopolysaccharide-induced cognitive impairment and neuroinflammation.
- Authors
Utcharaporn Kamsrijai; Benjamard Thaweethee-Sukjai; Narudol Teerapattarakan; Keerati Wanchai; Poonyawee Jirarattanawan
- Abstract
Introduction: Tacca chantrieri Andre is frequently used by traditional healers to alleviate pain and fever, primirily by reducing inflammation. Its rhizome extract possesses remarkable peripheral anti-inflammatory and antioxidant bioactivities. However, there is limited information available regarding its potential anti-neuroinflammation effects. This study aimes to assess the neuroprotective effects of T. chantrieri rhizome ethanol extract (TCE) against lipopolysaccharides (LPS)-induced neuroinflammation. Methods: Rats were orally administered with TCE at doses of 50, 100, and 200 mg/kg continually for 9 days. On the 7th day of treatment, each rat received a single intraperitoneal injection of LPS (0.83 mg/kg). Cognitive performance was assessed using the Y-maze test and novel object recognition (NOR) test. Thereafter, the proinflammatory cytokine level in the hippocampus was measured by ELISA. Results: Systemic LPS administration induced sickness behavior, cognitive impairment, and neuroinflammation. TCE at doses of 100 and 200 mg/kg reversed the LPS-induced behavioral deficits, showing improvements in spontaneous alternation in the Y-maze test and discrimination index in the NOR test. Additionally, pretreatment with TCE at doses of 100 and 200 mg/kg significantly attenuated the LPS-induced increase in protein expression of TNF-α. Conclusion: TCE exhibited neuroprotective effects against LPS-induced cognitive deficits and suppressed the production of pro-inflammatory mediators in a dose-dependent manner. These findings indicate that TCE may hold therapeutic potential in preventing neuroinflammationassociated cognitive impairment. However, further studies are necessary to validate the possible mechanisms of its neuroprotective effects.
- Subjects
COGNITION disorders; NEUROINFLAMMATION; NEUROPROTECTIVE agents; INTRAPERITONEAL injections; COGNITIVE ability; ETHANOL
- Publication
Physiology & Pharmacology, 2023, Vol 27, Issue 3, p296
- ISSN
1735-0581
- Publication type
Article
- DOI
10.61186/phypha.27.3.296