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- Title
Incidence, characteristics, and treatment outcomes of mycobacterial diseases in transplant recipients.
- Authors
Yoo, Jung-Wan; Jo, Kyung-Wook; Kim, Sung-Han; Lee, Sang-Oh; Kim, Jae Joong; Park, Su-Kil; Lee, Je-Hwan; Han, Duck Jong; Hwang, Shin; Lee, SeungGyu; Shim, Tae Sun
- Abstract
The incidence, clinical characteristics, and treatment outcomes of tuberculosis ( TB) and nontuberculous mycobacterial ( NTM) disease developed after transplantation ( TPL) in transplant recipients were investigated retrospectively. Between 1996 and 2013, 7342 solid-organ transplantation and 1266 hematopoietic stem cell transplantation were performed at a tertiary referral center in South Korea. Among them, TB and NTM disease developed in 130 and 22 patients, respectively. The overall incidence of TB was 257.4 cases/100 000 patient-years (95% confidence interval [ CI], 215.1-305.7) and that of NTM disease was 42.7 cases/100 000 patient-years (95% CI, 26.8-64.7). The median interval from organ TPL to the development of mycobacterial disease was 8.5 months (95% CI, 6.3-11.4) in recipients with TB patients and 24.2 months (95% CI, 13.5-55.7) in those with NTM, respectively. Among NTM patients, Mycobacterium avium-intracellulare complex was the most common causative organism, and nodular bronchiectatic type (77.8%) was the most frequent radiologic feature. Favorable treatment outcome was achieved in 83.7% (95% CI, 76.4-89.1) and 68.8% (95% CI, 44.4-85.8) of TB and NTM patients, respectively ( P = 0.166). In conclusion, the overall incidence of TB was higher than that of NTM disease in transplant recipients and treatment outcomes were favorable in both drug-susceptible TB and NTM patients.
- Subjects
HEALTH outcome assessment; MYCOBACTERIAL diseases; HEMATOPOIETIC stem cell transplantation; TRANSPLANTATION of organs, tissues, etc.; MYCOBACTERIAL disease treatment; MYCOBACTERIAL disease diagnosis
- Publication
Transplant International, 2016, Vol 29, Issue 5, p549
- ISSN
0934-0874
- Publication type
Article
- DOI
10.1111/tri.12752